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A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4+ and CD8+ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection.
Zayou, Latifa; Prakash, Swayam; Dhanushkodi, Nisha Rajeswari; Quadiri, Afshana; Ibraim, Izabela Coimbra; Singer, Mahmoud; Salem, Amirah; Shaik, Amin Mohammed; Suzer, Berfin; Chilukuri, Amruth; Tran, Jennifer; Nguyen, Pauline Chau; Sun, Miyo; Hormi-Carver, Kathy K; Belmouden, Ahmed; Vahed, Hawa; Gil, Daniel; Ulmer, Jeffrey B; BenMohamed, Lbachir.
Afiliação
  • Zayou L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Prakash S; Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
  • Dhanushkodi NR; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Quadiri A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Ibraim IC; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Singer M; High containment facility, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Salem A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Shaik AM; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Suzer B; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Chilukuri A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Tran J; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Nguyen PC; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Sun M; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Hormi-Carver KK; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Belmouden A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA.
  • Vahed H; Laboratory of Cell Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
  • Gil D; Department of Vaccines and Immunotherapies, TechImmune, LLC, University Lab Partners, Irvine, California, USA.
  • Ulmer JB; Department of Vaccines and Immunotherapies, TechImmune, LLC, University Lab Partners, Irvine, California, USA.
  • BenMohamed L; Department of Vaccines and Immunotherapies, TechImmune, LLC, University Lab Partners, Irvine, California, USA.
J Virol ; 97(12): e0109623, 2023 Dec 21.
Article em En | MEDLINE | ID: mdl-38038432
ABSTRACT
IMPORTANCE Although the current rate of SARS-CoV-2 infections has decreased significantly, COVID-19 still ranks very high as a cause of death worldwide. As of October 2023, the weekly mortality rate is still at 600 deaths in the United States alone, which surpasses even the worst mortality rates recorded for influenza. Thus, the long-term outlook of COVID-19 is still a serious concern outlining the need for the next-generation vaccine. This study found that a prime/pull coronavirus vaccine strategy increased the frequency of functional SARS-CoV-2-specific CD4+ and CD8+ memory T cells in the lungs of SARS-CoV-2-infected triple transgenic HLA-DR*0101/HLA-A*0201/hACE2 mouse model, thereby resulting in low viral titer and reduced COVID-19-like symptoms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article