Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation.

Boehme, Jason T; Sun, Xutong; Lu, Qing; Barton, Jubilee; Wu, Xiaomin; Gong, Wenhui; Raff, Gary W; Datar, Sanjeev A; Wang, Ting; Fineman, Jeffrey R; Black, Stephen M

Boehme, Jason T; Sun, Xutong; Lu, Qing; Barton, Jubilee; Wu, Xiaomin; Gong, Wenhui; Raff, Gary W; Datar, Sanjeev A; Wang, Ting; Fineman, Jeffrey R; Black, Stephen M.

Afiliação

Boehme JT; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA.
Sun X; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL, 34987-2352, USA; Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, 33199, USA.
Lu Q; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL, 34987-2352, USA; Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, 33199, USA.
Barton J; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA.
Wu X; Department of Medicine, University of Arizona Health Sciences, Tucson, AZ, 85719, USA.
Gong W; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA.
Raff GW; Department of Surgery, University of California Davis, Davis, CA, 95817, USA.
Datar SA; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA.
Wang T; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL, 34987-2352, USA; Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, 33199, USA.
Fineman JR; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 94143, USA.
Black SM; Center for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL, 34987-2352, USA; Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, 33199, USA; Department

Nitric Oxide ; 142: 58-68, 2024 Jan 01.

Article em En | MEDLINE | ID: mdl-38061411

Assuntos

Inibidores de Hidroximetilglutaril-CoA Redutases; Doenças Vasculares; Humanos; Criança; Animais; Ovinos; Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia; Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico; Sinvastatina/farmacologia; Sinvastatina/uso terapêutico; Sinvastatina/metabolismo; Células Endoteliais/metabolismo; Óxido Nítrico Sintase Tipo III/metabolismo; Endotélio/metabolismo; Doenças Vasculares/metabolismo; Óxido Nítrico/metabolismo; Endotélio Vascular/metabolismo

Palavras-chave

Akt1; CTMP; Congenital heart disease; Endothelial dysfunction; Endothelial nitric oxide synthase; Nitric oxide; Pulmonary hypertension; Pulmonary vascular disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Inibidores de Hidroximetilglutaril-CoA Redutases Limite: Animals / Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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