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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Huber, Andrew D; Poudel, Shyaron; Wu, Jing; Miller, Darcie J; Lin, Wenwei; Yang, Lei; Bwayi, Monicah N; Rimmer, Mary Ashley; Gee, Rebecca R Florke; Seetharaman, Jayaraman; Chai, Sergio C; Chen, Taosheng.
Afiliação
  • Huber AD; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Poudel S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Wu J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Miller DJ; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Lin W; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Bwayi MN; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Rimmer MA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Gee RRF; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Seetharaman J; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Chai SC; Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  • Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Nucleic Acids Res ; 52(4): 1661-1676, 2024 Feb 28.
Article em En | MEDLINE | ID: mdl-38084912
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azepinas / Triazóis / Receptor de Pregnano X Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azepinas / Triazóis / Receptor de Pregnano X Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article