Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism.
Physiol Res
; 72(S4): S357-S363, 2023 12 17.
Article
em En
| MEDLINE
| ID: mdl-38116772
ABSTRACT
Multiglandular primary hyperparathyroidism (MGD) represents a rare form of primary hyperparathyroidism (PHPT). MGD is associated with hereditary PHPT, but the sporadic MGD is more common and affects a similar patient profile as single gland parathyroid disease (SGD). The distinction between SGD and MGD is of great clinical importance, especially for the strategy of parathyroidectomy. Based on the limited knowledge available, MGD is likely to be a genetically heterogeneous disease resulting from the interaction of germline and somatic DNA mutations together with epigenetic alterations. Furthermore, these events may combine and occur independently in parathyroid tumors within the same individual with MGD. Gene expression profiling has shown that SGD and MGD may represent distinct entities in parathyroid tumorigenesis. We are waiting for studies to analyze exactly which genes are different in SGD and MGD in order to identify potential biomarkers that can distinguish between the two forms of the disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hiperparatireoidismo Primário
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article