Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti-tumor Metallic complexes.
Chem Asian J
; 19(3): e202301020, 2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-38149729
ABSTRACT
Metal complexes represented by platinum complexes play a very important role in cancer treatment due to their diverse chemical structures and anti-tumor activities. Recently, ferroptosis has emerged as a newly occurring cell death form in the anti-tumor process. It has been reported that metal complexes could inhibit the proliferation and metastasis of tumors and combat chemotherapy resistance by targeting ferroptosis. In this review, we briefly describe ferroptosis as a fundamental process for tumor suppression and triggering anti-tumor immune responses. We summarize recent developments on metal complexes that induce ferroptosis. Finally, we outline the prospects for the application of metal complexes to the treatment of tumors based on ferroptosis and the associated problems that need to be solved, and discussed other potential research directions of metal complexes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexos de Coordenação
/
Ferroptose
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article