Effect of 5-aminolevulinic Acid on Mitochondrial Activity.
Front Biosci (Schol Ed)
; 15(4): 17, 2023 12 27.
Article
em En
| MEDLINE
| ID: mdl-38163956
ABSTRACT
BACKGROUND:
Mitochondrial dysfunction is considered an important mechanism in the pathogenesis of various diseases. Therefore, mitochondria are currently being considered as subjects for targeted therapies, particularly, phototherapy using 5-aminolevulinic acid. This study aimed to investigate the activity of mitochondria in cells with different mutation loads. MATERIALS ANDMETHODS:
The study was conducted using 11 cybrid lines obtained from the THP-1 cell line (a human monocytic leukemia cell line) and platelets of patients with different mitochondrial mutations.RESULTS:
Our results illustrate that 5-aminolevulinic acid was metabolized equally in all cell lines, however, there was a significant decrease in mitochondrial potential, which differed among lines.CONCLUSIONS:
The results of this study can be used to develop a personalized therapeutic approach based on different mitochondrial activities.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fármacos Fotossensibilizantes
/
Ácido Aminolevulínico
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article