Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis.

Duster, Nicole; Ramchandar, Nanda; Foley, Jennifer; Farnaes, Lauge; Coufal, Nicole G

Duster, Nicole; Ramchandar, Nanda; Foley, Jennifer; Farnaes, Lauge; Coufal, Nicole G.

Afiliação

Duster N; University of California San Diego, Department of Pediatrics, San Diego, CA, USA; Rady Children's Hospital, San Diego, CA, USA.
Ramchandar N; University of California San Diego, Department of Pediatrics, San Diego, CA, USA; Rady Children's Hospital, San Diego, CA, USA; Naval Medical Center San Diego, San Diego, CA, USA.
Foley J; Rady Children's Hospital, San Diego, CA, USA.
Farnaes L; University of California San Diego, Department of Pediatrics, San Diego, CA, USA; Rady Children's Hospital, San Diego, CA, USA.
Coufal NG; University of California San Diego, Department of Pediatrics, San Diego, CA, USA; Rady Children's Hospital, San Diego, CA, USA. Electronic address: ncoufal@health.ucsd.edu.

J Microbiol Methods ; 217-218: 106887, 2024.

Article em En | MEDLINE | ID: mdl-38169204

ABSTRACT

ABSTRACT

This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative pathogen in 36% of 28 subjects, compared to 50% for diverse conventional testing (57% combined). CFPNGS may be considered as an adjunct to standard testing.

Assuntos

Meningite; Humanos; Criança; Estudos Retrospectivos; Meningite/diagnóstico; Sequenciamento de Nucleotídeos em Larga Escala; Tecnologia; Metagenômica

Palavras-chave

CNS infection; Cell-free plasma sequencing; Meningitis; Metagenomics; NGS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Meningite Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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