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Prognostic impact of pretreatment cell-free DNA concentration in newly diagnosed peripheral T-cell lymphomas.
Fardella, E; Zanirato, G; Magni, M; Caldarelli, N; Chiappella, A; Dodero, A; Ljevar, S; Orsucci, L; Re, A; Usai, S V; Stefoni, V; Castellino, C; Rossi, F G; Pinto, A; Carniti, C; Corradini, P.
Afiliação
  • Fardella E; University of Milan, Milan, Italy.
  • Zanirato G; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Magni M; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Caldarelli N; University of Milan, Milan, Italy.
  • Chiappella A; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Dodero A; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Ljevar S; Unit of Biostatistics for Clinical Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Orsucci L; Division of Hematology, Azienda Ospedaliera e Universitaria Città della Salute e della Scienza, Turin, Italy.
  • Re A; Hematology Division, ASST Spedali Civili di Brescia, Brescia, Italy.
  • Usai SV; Hematology Unit, Ospedale Oncologico Armando Businco, Cagliari, Italy.
  • Stefoni V; Institute of Hematology Seràgnoli, University of Bologna, Bologna, Italy.
  • Castellino C; Division of Hematology, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy.
  • Rossi FG; Division of Hematology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
  • Pinto A; Hematology-Oncology & Stem Cell Transplantation Unit, IRCCS Istituto Nazionale Tumori, Fondazione G. Pascale, Napoli, Italy.
  • Carniti C; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Corradini P; University of Milan, Milan, Italy.
Br J Haematol ; 204(5): 1752-1756, 2024 May.
Article em En | MEDLINE | ID: mdl-38176400
ABSTRACT
Peripheral T-cell lymphomas (PTCLs) have a poor prognosis and, to date, there are no reliable predictive biomarkers of response. In this work we explored the prognostic impact of cell-free DNA (cfDNA) concentration in 75 newly diagnosed patients enrolled in a prospective multicenter study. Pre-treatment cfDNA was strongly associated with clinical risk factors and was identified as a superior predictor for shorter progression-free survival in multivariable analysis, outweighing canonical risk parameters. Furthermore, we identified a cfDNA value above which survival worsens. In conclusion, pre-treatment cfDNA concentration represents an easily usable predictive biomarker that is highly associated with survival of PTCL patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma de Células T Periférico / Ácidos Nucleicos Livres Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma de Células T Periférico / Ácidos Nucleicos Livres Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article