Construction and Application of a Pepsin-Functionalized Covalent Organic Framework with Prominent Chiral Recognition Ability.

Zhang, Jiale; Liu, Xue; Mu, Qixuan; Li, Ruijun; Ji, Yibing

Zhang, Jiale; Liu, Xue; Mu, Qixuan; Li, Ruijun; Ji, Yibing.

Afiliação

Zhang J; Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
Liu X; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing, 210009, China.
Mu Q; Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
Li R; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing, 210009, China.
Ji Y; Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China.

Chemistry ; 30(15): e202303827, 2024 Mar 12.

Article em En | MEDLINE | ID: mdl-38183168

ABSTRACT

ABSTRACT

The stable Pepsin@covalent organic framework (Pepsin@COF) were constructed base on matching COF pore diameter to pepsin dimension. It exhibits excellent chiral recognition capabilities (e. e. % up to 62.63 %) and potential for enantioseparation. Furthermore, a positive correlation between the immobilized enzyme activity and chiral recognition was revealed, offering insights for the design of biocatalytic nanosystems in chiral separation.

Palavras-chave

covalent organic framework; enantioselective recognition; enantioseparation; enzymatic activity; pepsin

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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