TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA.
Dokl Biochem Biophys
; 514(1): 11-15, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38189888
ABSTRACT
The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to the cytoplasm through the nuclear pores. However, the role of this complex in the export of other types of RNA remains unknown. We have shown that TREX-2-ORC participates in the nuclear export of histone mRNAs it associates with histone mRNPs, binds to histone H3 mRNA at the 3'-terminal part of the coding region, and participates in the export of histone mRNAs from the nucleus to the cytoplasm.
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Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Drosophila melanogaster
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article