Bufotalin-loaded biomimetic Prussian blue nanoparticles for colorectal cancer chemo-photothermal ferroptosis therapy.
Nanomedicine (Lond)
; 19(2): 109-125, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-38197393
ABSTRACT
Purpose:
We constructed biomimetic nanoparticles with biocompatible, tumor-targeting, laser-responsive properties for ferroptosis-induced colorectal cancer chemo-photothermal therapy, with the aim to realize double-hit ferroptosis treatment for colorectal cancer.Methods:
The nanoparticles were prepared by first loading the chemotherapy drug bufotalin (CS-5) with Prussian blue (PB), then combining a hybridized erythrocyte-tumor membrane (M) with PB@CS-5 to produce PB@CS-5@M. The chemo-photothermal therapy efficiency of PB@CS-5@M was tested by in vitro and in vivo experiments. Results andconclusion:
The combined PB and CS-5 act as promising ferroptosis inducers to enhance ferroptosis efficacy. The hyperthermia induced by laser stimulation can trigger PB to release CS-5 and iron and ferrous ions, which further promotes ferroptosis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bufanolídeos
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Neoplasias Colorretais
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Nanopartículas
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Ferrocianetos
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Ferroptose
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Hipertermia Induzida
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article