Effectiveness and safety of intravesical Gentamicin therapy in patients with recurrent urinary tract infections caused by multidrug resistant organisms.
J Pak Med Assoc
; 74(1): 118-122, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38219177
ABSTRACT
A prospective study was conducted at the Liaquat National Hospital and Medical College, Karachi, to determine the effectiveness, feasibility, and safety of intravesical Gentamicin therapy among patients presenting with recurrent urinary tract infections (rUTIs). All patients aged ≥15 years, who presented with recurrent UTI, having ≥3 positive urine cultures, with neurogenic bladder, intermittent catheterisation, symptomatic UTIs, and multidrug resistant cultures, were included in the study. Data were compiled and analysed using SPSS version 26. An ethics committee approved the study. A total of 69 patients were enrolled. Most common organisms were Klebsiella (52.2%), E. coli (27.5%) and gram -ve bacilli (14.5%). Multi drug resistance was observed in 18 (26.1%) patients, while effectiveness and safety were reported in 62 (89.9%) and 65 (94.2%) patients, respectively. Intravesical Gentamicin may be helpful in reducing the frequency of episodes and need for oral antibiotics in patients with UTIs, and demonstrated effectiveness and safety in most patients.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Urinárias
/
Gentamicinas
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article