A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity.
Molecules
; 29(2)2024 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-38257377
ABSTRACT
A facile methodology for the construction of a complex heterocycle indazolo-fused quinoxalinone has been developed via an Ugi four-component reaction (U-4CR) followed by an intramolecular Ullmann reaction. The expeditious process features an operationally simple approach, time efficiency, and a broad substrate scope. Biological activity was evaluated and demonstrated that compound 6e inhibits human colon cancer cell HCT116 proliferation with an IC50 of 2.1 µM, suggesting potential applications for developing a drug lead in medicinal chemistry.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Neoplasias do Colo
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article