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Effects of a liquefied petroleum gas stove intervention on stillbirth, congenital anomalies and neonatal mortality: A multi-country household air pollution intervention network trial.
Younger, Ashley; Ye, Wenlu; Alkon, Abbey; Harknett, Kristen; Kirby, Miles A; Elon, Lisa; Lovvorn, Amy E; Wang, Jiantong; Diaz-Artiga, Anaité; McCracken, John P; Castañaza Gonzalez, Adly; Alarcon, Libny Monroy; Mukeshimana, Alexie; Rosa, Ghislaine; Chiang, Marilu; Balakrishnan, Kalpana; Garg, Sarada S; Pillarisetti, Ajay; Piedrahita, Ricardo; Johnson, Michael A; Craik, Rachel; Papageorghiou, Aris T; Toenjes, Ashley; Williams, Kendra N; Underhill, Lindsay J; Hartinger, Stella M; Nicolaou, Laura; Chang, Howard H; Naeher, Luke P; Rosenthal, Joshua; Checkley, William; Peel, Jennifer L; Clasen, Thomas F; Thompson, Lisa M.
Afiliação
  • Younger A; School of Nursing, University of California, San Francisco, CA, USA. Electronic address: ashley.younger@wrh.ox.ac.uk.
  • Ye W; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Alkon A; School of Nursing, University of California, San Francisco, CA, USA.
  • Harknett K; School of Nursing, University of California, San Francisco, CA, USA.
  • Kirby MA; Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Elon L; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Lovvorn AE; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, CA, USA.
  • Wang J; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Diaz-Artiga A; Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • McCracken JP; Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala; Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA, USA.
  • Castañaza Gonzalez A; Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • Alarcon LM; Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
  • Mukeshimana A; Eagle Research Centre, Kigali, Rwanda.
  • Rosa G; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
  • Chiang M; Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Balakrishnan K; Department of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India.
  • Garg SS; Department of Environmental Health Engineering, ICMR Center for Advanced Research on Air Quality, Climate and Health, Sri Ramachandra Institute for Higher Education and Research (Deemed University), Chennai, India.
  • Pillarisetti A; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Piedrahita R; Berkeley Air Monitoring Group, Berkeley, CA, USA.
  • Johnson MA; Berkeley Air Monitoring Group, Berkeley, CA, USA.
  • Craik R; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
  • Papageorghiou AT; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
  • Toenjes A; Cardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
  • Williams KN; Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Underhill LJ; Cardiovascular Division, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
  • Hartinger SM; Latin American Center of Excellence on Climate Change and Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Nicolaou L; Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Chang HH; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Naeher LP; Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA, USA.
  • Rosenthal J; Division of Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
  • Checkley W; Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Peel JL; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
  • Clasen TF; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, CA, USA.
  • Thompson LM; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, CA, USA; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Environ Pollut ; 345: 123414, 2024 Mar 15.
Article em En | MEDLINE | ID: mdl-38286258
ABSTRACT
Household air pollution (HAP) from cooking with solid fuels used during pregnancy has been associated with adverse pregnancy outcomes. The Household Air Pollution Intervention Network (HAPIN) trial was a randomized controlled trial that assessed the impact of a liquefied petroleum gas (LPG) stove and fuel intervention on health in Guatemala, India, Peru, and Rwanda. Here we investigated the effects of the LPG stove and fuel intervention on stillbirth, congenital anomalies and neonatal mortality and characterized exposure-response relationships between personal exposures to fine particulate matter (PM2.5), black carbon (BC) and carbon monoxide (CO) and these outcomes. Pregnant women (18 to <35 years of age; gestation confirmed by ultrasound at 9 to <20 weeks) were randomly assigned to intervention or control arms. We monitored these fetal and neonatal outcomes and personal exposure to PM2.5, BC and CO three times during pregnancy, we conducted intention-to-treat (ITT) and exposure-response (E-R) analyses to determine if the HAPIN intervention and corresponding HAP exposure was associated with the risk of fetal/neonatal outcomes. A total of 3200 women (mean age 25.4 ± 4.4 years, mean gestational age at randomization 15.4 ± 3.1 weeks) were included in this analysis. Relative risks for stillbirth, congenital anomaly and neonatal mortality were 0.99 (0.60, 1.66), 0.92 (95 % CI 0.52, 1.61), and 0.99 (0.54, 1.85), respectively, among women in the intervention arm compared to controls in an ITT analysis. Higher mean personal exposures to PM2.5, CO and BC during pregnancy were associated with a higher, but statistically non-significant, incidence of adverse outcomes. The LPG stove and fuel intervention did not reduce the risk of these outcomes nor did we find evidence supporting an association between personal exposures to HAP and stillbirth, congenital anomalies and neonatal mortality.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Petróleo / Poluição do Ar em Ambientes Fechados / Poluição do Ar Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Petróleo / Poluição do Ar em Ambientes Fechados / Poluição do Ar Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article