Lipoprotein signal peptidase-deficient Streptococcus pneumoniae exhibits impaired Toll-like receptor 2-stimulatory activity.
Microbiol Immunol
; 68(4): 155-159, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38311883
ABSTRACT
Streptococcus pneumoniae is a causative agent of community-acquired pneumonia. Upon pneumococcal infection, innate immune cells recognize pneumococcal lipoproteins via Toll-like receptor 2 and induce inflammation. Here, we generated a strain of S. pneumoniae deficient in lipoprotein signal peptidase (LspA), a transmembrane type II signal peptidase required for lipoprotein maturation, to investigate the host immune response against this strain. Triton X-114 phase separation revealed that lipoprotein expression was lower in the LspA-deficient strain than in the wild-type strain. Additionally, the LspA-deficient strain decreased nuclear factor-κB activation and cytokine production in THP-1 cells, indicating impaired innate immune response against the strain.
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Base de dados:
MEDLINE
Assunto principal:
Streptococcus pneumoniae
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Ácido Aspártico Endopeptidases
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Receptor 2 Toll-Like
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article