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Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[cd]indole-2(1H)-ketone.
Qin, Hongshuang; Li, Lin; Chen, Shuhan; Han, Xuwei; Min, Runan; Guo, Yanxiang; Liu, Tao; Zhao, Chuanqi.
Afiliação
  • Qin H; Department of Life Science, Lyuliang University, Lvliang, Shanxi 033001, P. R. China.
  • Li L; Department of Life Science, Lyuliang University, Lvliang, Shanxi 033001, P. R. China.
  • Chen S; Department of Life Science, Lyuliang University, Lvliang, Shanxi 033001, P. R. China.
  • Han X; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi 030006, P. R. China.
  • Min R; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi 030006, P. R. China.
  • Guo Y; Department of Life Science, Lyuliang University, Lvliang, Shanxi 033001, P. R. China.
  • Liu T; Department of Chemistry and Chemical Engineering, Lyuliang University, Lvliang, Shanxi 033001, P. R. China. liutao@llu.edu.cn.
  • Zhao C; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China. zhaocq@ciac.ac.cn.
J Mater Chem B ; 12(10): 2481-2485, 2024 Mar 06.
Article em En | MEDLINE | ID: mdl-38375678
ABSTRACT
6-Nitrobenzo[cd]indole-2(1H)-ketone (compound C2) exhibits an excellent germicidal effect against methicillin-resistant Staphylococcus aureus (MRSA). Mechanism studies show that C2 induces ROS over-production, cell membrane damage, and ATP and virulence factor down-regulation in bacteria. More importantly, C2 can inhibit biofilm formation and accelerate wound healing in a mouse infection model induced by MRSA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus Resistente à Meticilina Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Staphylococcus aureus Resistente à Meticilina Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article