Asymmetric Brominative Dearomatization of 2-Naphthols Using a Cinchona Alkaloid-Based Organocatalyst.

Omae, Kouhei; Miyake, Yoshihiro; Shimogaki, Mio

Omae, Kouhei; Miyake, Yoshihiro; Shimogaki, Mio.

Afiliação

Omae K; Department of Material Science, Graduate School of Science, University of Hyogo, Kouto, Kamigori, Hyogo 678-1297, Japan.
Miyake Y; Department of Material Science, Graduate School of Science, University of Hyogo, Kouto, Kamigori, Hyogo 678-1297, Japan.
Shimogaki M; Department of Material Science, Graduate School of Science, University of Hyogo, Kouto, Kamigori, Hyogo 678-1297, Japan.

J Org Chem ; 89(6): 4232-4236, 2024 Mar 15.

Article em En | MEDLINE | ID: mdl-38437503

ABSTRACT

ABSTRACT

A cinchona alkaloid-based organocatalyst enables asymmetric brominative dearomatization of 2-naphthols, providing the corresponding bromonaphthalenones with high enantioselectivities. The first metal-free reaction can accommodate a variety of functional groups and give useful frameworks bearing a Br-containing tetrasubstituted stereogenic center.

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article