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Prediction of preterm birth in women with fetal growth restriction - Is the weekly change in sFlt-1/PlGF ratio or PlGF levels useful?
Hong, Jesrine; Crawford, Kylie; Cavanagh, Erika; Clifton, Vicki; Kumar, Sailesh.
Afiliação
  • Hong J; Mater Research Institute, University of Queensland, South Brisbane, Queensland, Australia.
  • Crawford K; Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
  • Cavanagh E; Department of Obstetrics and Gynecology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
  • Clifton V; Mater Research Institute, University of Queensland, South Brisbane, Queensland, Australia.
  • Kumar S; Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.
Acta Obstet Gynecol Scand ; 103(6): 1112-1119, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38483020
ABSTRACT

INTRODUCTION:

To assess the rate of change in soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PlGF) ratio and PlGF levels per week compared to a single sFlt-1/PlGF ratio or PlGF level to predict preterm birth for pregnancies complicated by fetal growth restriction. MATERIAL AND

METHODS:

A prospective cohort study of pregnancies complicated by isolated fetal growth restriction. Maternal serum PlGF levels and the sFlt-1/PlGF ratio were measured at 4-weekly intervals from recruitment to delivery. We investigated the utility of PlGF levels, sFlt-1/PlGF ratio, change in PlGF levels per week or sFlt-1/PlGF ratio per week. Cox-proportional hazard models and Harrell's C concordance statistic were used to evaluate the effect of biomarkers on time to preterm birth.

RESULTS:

The total study cohort was 158 pregnancies comprising 91 (57.6%) with fetal growth restriction and 67 (42.4%) with appropriate for gestational age controls. In the fetal growth restriction cohort, sFlt-1/PlGF ratio and PlGF levels significantly affected time to preterm birth (Harrell's C 0.85-0.76). The rate of increase per week of the sFlt-1/PlGF ratio (hazard ratio [HR] 3.91, 95% confidence interval [CI] 1.39-10.99, p = 0.01, Harrell's C 0.74) was positively associated with preterm birth but change in PlGF levels per week was not (HR 0.65, 95% CI 0.25-1.67, p = 0.37, Harrell's C 0.68).

CONCLUSIONS:

Both a high sFlt-1/PlGF ratio and low PlGF levels are predictive of preterm birth in women with fetal growth restriction. Although the rate of increase of the sFlt-1/PlGF ratio predicts preterm birth, it is not superior to either a single elevated sFlt-1/PlGF ratio or low PlGF level.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Receptor 1 de Fatores de Crescimento do Endotélio Vascular / Nascimento Prematuro / Retardo do Crescimento Fetal / Fator de Crescimento Placentário Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores / Receptor 1 de Fatores de Crescimento do Endotélio Vascular / Nascimento Prematuro / Retardo do Crescimento Fetal / Fator de Crescimento Placentário Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article