Cell and gene therapy investment: evolution and future outlook on investor perspectives.
Cytotherapy
; 26(7): 672-680, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38483363
ABSTRACT
BACKGROUND AIMS:
To better understand the attitudes and behaviors of investors involved in funding cell and gene therapy (CGT) businesses, the Business Development and Finance) subcommittee of International Society for Cell and Gene Therapy, in collaboration with Truist Securities, conducted a broad survey of the investment community in late 2021.METHODS:
This survey follows a similar study that this group executed in 2018, and the longitudinal comparisons between the two time periods provide insights into how investor behavior in the CGT field has evolved.RESULTS:
The vast majority of investor respondents are specialist biotech investors who are primarily active in deploying capital in North America and Europe. There was a notable increase in the proportion of investors actively deploying capital in China and Japan between 2018 and 2021. The percentage of respondents' portfolios dedicated to CGT companies has also increased in this period, reflecting a noteworthy trend in the therapeutic landscape.CONCLUSIONS:
Clinically significant data remain the dominant force behind investment decisions, whereas competition from other drug modalities has now emerged as the most-cited barrier to making a CGT investment, eclipsing safety concerns as the most significant barrier to investment in 2018. Concerns around manufacturing and scale-up have also increased in prominence amongst the investment community. Gene-editing technologies are attracting investors as the most compelling new CGT technology. This survey also revealed that most investors expect to increase their level of investment in allogeneic technologies relative to autologous products in the coming years.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Terapia Baseada em Transplante de Células e Tecidos
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Investimentos em Saúde
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article