Evaluation of behavioral variance/covariance explained by the neuroimaging data through a pattern-based regression.
Hum Brain Mapp
; 45(4): e26601, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38488475
ABSTRACT
Neuroimaging data have been widely used to understand the neural bases of human behaviors. However, most studies were either based on a few predefined regions of interest or only able to reveal limited vital regions, hence not providing an overarching description of the relationship between neuroimaging and behaviors. Here, we proposed a voxel-based pattern regression that not only could investigate the overall brain-associated variance (BAV) for a given behavioral measure but could also evaluate the shared neural bases between different behaviors across multiple neuroimaging data. The proposed method demonstrated consistently high reliability and accuracy through comprehensive simulations. We further implemented this approach on real data of adolescents (IMAGEN project, n = 2089) and adults (HCP project, n = 808) to investigate brain-based variances of multiple behavioral measures, for instance, cognitive behaviors, substance use, and psychiatric disorders. Notably, intelligence-related scores showed similar high BAVs with the gray matter volume across both datasets. Further, our approach allows us to reveal the latent brain-based correlation across multiple behavioral measures, which are challenging to obtain otherwise. For instance, we observed a shared brain architecture underlying depression and externalizing problems in adolescents, while the symptom comorbidity may only emerge later in adults. Overall, our approach will provide an important statistical tool for understanding human behaviors using neuroimaging data.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Relacionados ao Uso de Substâncias
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Neuroimagem
Limite:
Adolescent
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Adult
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article