Utilization of Anti-obesity Medications After Bariatric Surgery: Analysis of a Large National Database.
Obes Surg
; 34(5): 1415-1424, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38512645
ABSTRACT
PURPOSE:
A significant proportion of patients experience insufficient weight loss or weight regain after bariatric surgery. There is a paucity of literature describing anti-obesity medication (AOM) use following bariatric surgery. We sought to identify prevalence and trends of AOM use following bariatric surgery. MATERIALS ANDMETHODS:
We utilized the IBM Explorys® database to identify all adults with prior bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy). Those prescribed AOMs (semaglutide, liraglutide, topiramate, phentermine/topiramate, naltrexone/bupropion, orlistat) within 5 years of surgery were further identified. Data was analyzed to characterize AOM utilization among different age, demographic, and comorbid populations.RESULTS:
A total of 59,160 adults with prior bariatric surgery were included. Among AOMs studies, prevalence of use was highest for topiramate (8%), followed by liraglutide (2.9%), phentermine/topiramate (1.03%), naltrexone/bupropion (0.95%) semaglutide (0.52%), and orlistat (0.17%). Age distribution varied, with the highest utilization among those age 35-39 years for topiramate, 40-44 years for phentermine/topiramate and naltrexone/bupropion, 45-49 years for semaglutide, and 65-69 years for liraglutide and orlistat. African American race was associated with higher utilization across all AOMs. Among comorbidities, hypertension, hyperlipidemia, and diabetes mellitus were most associated with AOM use.CONCLUSION:
Despite a relatively high incidence of weight regain, AOMs are underutilized following bariatric surgery. It is imperative that barriers to their use be addressed and that AOMs be considered earlier and more frequently in patients with insufficient weight loss or weight regain after bariatric surgery.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Artrite
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Obesidade Mórbida
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Descolamento Retiniano
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Derivação Gástrica
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Doenças do Tecido Conjuntivo
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Fármacos Antiobesidade
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Cirurgia Bariátrica
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Perda Auditiva Neurossensorial
Limite:
Adult
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article