Coexpression of translocated and normal c-myc oncogenes in hybrids between Daudi and lymphoblastoid cells.
Science
; 227(4691): 1235-8, 1985 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-3856319
ABSTRACT
Mechanisms that affect the transcription of the c-myc oncogene take part in the development of B-cell neoplasias such as Burkitt's lymphoma. Daudi Burkitt lymphoma cells, which express only the translocated c-myc oncogene, were hybridized with human lymphoblastoid cells, which express the normal c-myc gene; the hybrids were phenotypically lymphoblastoid and expressed both the translocated and the normal c-myc gene. This result contrasts with the findings that the decapitated c-myc gene, translocated to an immunoglobulin switch mu or alpha region, is transcriptionally silent in lymphoblastoid hybrids. Thus, there may be at least two distinct enhancer-like elements capable of deregulating c-myc transcription in lymphomas and leukemias with t(8;14) chromosome translocations. In addition, since the Daudi X lymphoblastoid hybrids express both the translocated and the normal c-myc gene, the c-myc gene product does not autoregulate c-myc transcription.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Translocação Genética
/
Leucemia Linfoide
/
Linfoma de Burkitt
Limite:
Humans
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article