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Molecular mechanisms in the pathogenesis of dengue infections.
Malavige, Gathsaurie Neelika; Ogg, Graham S.
Afiliação
  • Malavige GN; Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka; Medical Research Council (MRC) Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Electronic address: gathsaurie.malavige@ndm.ox.ac.uk.
  • Ogg GS; Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka; Medical Research Council (MRC) Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Trends Mol Med ; 30(5): 484-498, 2024 May.
Article em En | MEDLINE | ID: mdl-38582622
ABSTRACT
Dengue is the most rapidly emerging climate-sensitive infection, and morbidity/mortality and disease incidence are rising markedly, leading to healthcare systems being overwhelmed. There are currently no specific treatments for dengue or prognostic markers to identify those who will progress to severe disease. Owing to an increase in the burden of illness and a change in epidemiology, many patients experience severe disease. Our limited understanding of the complex mechanisms of disease pathogenesis has significantly hampered the development of safe and effective treatments, vaccines, and biomarkers. We discuss the molecular mechanisms of dengue pathogenesis, the gaps in our knowledge, and recent advances, as well as the most crucial questions to be answered to enable the development of therapeutics, biomarkers, and vaccines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dengue / Vírus da Dengue Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dengue / Vírus da Dengue Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article