Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice.
Nat Commun
; 15(1): 3034, 2024 Apr 08.
Article
em En
| MEDLINE
| ID: mdl-38589429
ABSTRACT
Chronic stress induces anxiety disorders via both neural pathways and circulating factors. Although many studies have elucidated the neural circuits involved in stress-coping behaviors, the origin and regulatory mechanism of peripheral cytokines in behavioural regulation under stress conditions are not fully understood. Here, we identified a serum cytokine, lipocalin 2 (LCN2), that was upregulated in participants with anxiety disorders. Using a mouse model of chronic restraint stress (CRS), circulating LCN2 was found to be related to stress-induced anxiety-like behaviour via modulation of neural activity in the medial prefrontal cortex (mPFC). These results suggest that stress increases hepatic LCN2 via a neural pathway, leading to disrupted cortical functions and behaviour.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Córtex Pré-Frontal
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article