[Molecular markers for predicting the success of micro-TESE in non-obstructive azoospermia].
Zhonghua Nan Ke Xue
; 29(9): 851-855, 2023 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-38639601
ABSTRACT
Non-obstract azoospermia (NOA) is a serious male infertility disease. At present, testicular sperm extraction (micro-TESE) is performed in combination with intracytoplasmic sperm injection (ICSI) technology, NOA patients can have their own consanguine offspring. However, due to the invasiveness and uncertainty of micro-TESE surgery, it is difficult for patients to accept it. Therefore, finding an accurate method to predict the possibility of micro-TESE successful sperm retrival would be beneficial to azoospermia patients. Many genes are transcribed and expressed during spermatogenesis, and molecular assays have irreplaceable sensitivity and specificity in predicting the success sperm retrivel of micro-TESE. This article reviews the methods to predict the success sperm retrivel of micro-TESE including mRNA, non-coding RNA (piRNA, microRNA, cirRNA, tFRNAs) and some protein so far, to provide certain reference value for clinical and subsequent research.
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Base de dados:
MEDLINE
Assunto principal:
Azoospermia
Limite:
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2023
Tipo de documento:
Article