Exploring the efficacy of photodynamic antimicrobial chemotherapy on diabetic foot ulcers in rats.
J Biophotonics
; 17(7): e202300568, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38651324
ABSTRACT
We investigate the efficacy of photodynamic antimicrobial chemotherapy (PACT) and its combination with an antibiotic in the treatment of diabetic foot ulcers (DFUs) in rats using a novel cationic amino acid porphyrin-based photosensitizer. The research findings demonstrate that the combination of novel cationic photosensitizer-mediated PACT and an antibiotic exhibits significant therapeutic efficacy in treating deep ulcers in a rat model of DFUs. Moreover, the PACT + Antibiotic group displays enhanced angiogenesis, improved tissue maturation, and superior wound healing effect. Micro-computed tomography examination showed that the periosteal reaction was most obvious in the PACT + Antibiotic group. The cortical bone volume ratio (BV/TV), the bone mineral density, and trabecular thickness were significantly higher in the PACT + Antibiotic group than in the model group (p < 0.05). The combination of PACT and antibiotic plays a sensitizing therapeutic role, which provides a new idea for the clinical treatment of DFUs.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Cicatrização
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Ratos Sprague-Dawley
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Fármacos Fotossensibilizantes
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Pé Diabético
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article