Targeted Knockdown of Hepatic Δ-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE-/- Mice.
Front Biosci (Landmark Ed)
; 29(4): 131, 2024 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-38682200
ABSTRACT
BACKGROUND:
The endogenous metabolism of polyunsaturated fatty acids is regulated by the fatty acid desaturase (FADS) gene cluster and is strongly associated with diseases such as atherosclerosis, dyslipidemia, and type 2 diabetes. However, the association between FADS and atherosclerosis remains a subject of debate.METHODS:
In this study, we specifically investigated the physiological role of Δ-5 fatty acid desaturase (FADS1) in aortic and peripheral vessel (namely, the femoral artery) atherosclerosis by targeting the selective knockdown of hepatic Fads1 in apolipoprotein E-null (ApoE-â£/-) mice with antisense oligonucleotides (ASOs).RESULTS:
Knockdown of hepatic Fads1 in ApoE-â£/- mice exacerbated aortic atherosclerosis and non-alcoholic fatty liver disease (NAFLD), resulting in weight loss. Upregulation of FADS1 mRNA expression in more severe atherosclerosis vascular tissues potentially caused the upregulation of angiopoietin-like 4 expression.CONCLUSIONS:
Our study demonstrated that knockdown of hepatic Fads1 in ApoE-â£/- mice aggravates spontaneous atherosclerosis and NAFLD but does not affect peripheral atherosclerosis (femoral artery) induced by vascular cuff combined with tandem stenosis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Aterosclerose
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Ácidos Graxos Dessaturases
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Dessaturase de Ácido Graxo Delta-5
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Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article