[The role of Th17 cells and IL-17 in Hashimoto's thyroiditis: Review].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 40(4): 373-377, 2024 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-38710521
ABSTRACT
Patients with Hashimoto's thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue, significantly elevated levels of interleukin 17 (IL-17), and an imbalance in the ratio of Th17 cells to regulatory T cells (Tregs). The reduced Tregs' ratio leads to a reduction in immunosuppressive function within the thyroid gland, while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Reguladores
/
Interleucina-17
/
Doença de Hashimoto
/
Células Th17
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article