Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too.
Eur J Neurol
; 31(8): e16328, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38720477
ABSTRACT
BACKGROUND AND PURPOSE:
Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.METHODS:
This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.RESULTS:
In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (ß = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (ß = 0.231 [95% CI = 0.124-3.639], p = 0.036).CONCLUSIONS:
Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fenótipo
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Transtornos Neurológicos da Marcha
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Disfunção Cognitiva
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Hidrocefalia de Pressão Normal
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article