Morphological and Neurological Impairments Induced by Chronic Administration of Dimethyl Sulfoxide in Mice.
Bull Exp Biol Med
; 176(5): 631-635, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38733477
ABSTRACT
We studied the influence of DMSO administered ad libitum with drinking water in concentrations of 0.01, 0.1, and 1% for 4 and 6 weeks on pain sensitivity, motor coordination, and myelin content in the corpus callosum of C57BL/6 mice. After 6-week administration, DMSO in all studied concentrations decreased myelin content in the corpus callosum. Moreover, 4-week administration of 0.1% DMSO and 6-week administration of 1% DMSO increased the latency to fall in the rotarod test by 3.1 (p<0.05) and 5.1 (p<0.001) times, respectively. After 4-week administration of DMSO in concentrations of 0.01 and 0.1%, the latency of the tail flick response increased by 2.1 (p<0.05) and 1.8 times (p<0.001), respectively. Administration of DMSO in concentrations of 0.01 and 1% for 6 weeks led to a decrease of this parameter by 2.7 (p<0.05) and 3.8 times (p<0.01), respectively. Thus, DMSO in all studied concentrations decreased myelin content in the corpus callosum of C57BL/6 mice and modified motor coordination and pain sensitivity of animals.
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Base de dados:
MEDLINE
Assunto principal:
Dimetil Sulfóxido
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Corpo Caloso
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Camundongos Endogâmicos C57BL
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Bainha de Mielina
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article