Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis.
Development
; 151(10)2024 May 15.
Article
em En
| MEDLINE
| ID: mdl-38738602
ABSTRACT
Visual circuit development is characterized by subdivision of neuropils into layers that house distinct sets of synaptic connections. We find that, in the Drosophila medulla, this layered organization depends on the axon guidance regulator Plexin A. In Plexin A null mutants, synaptic layers of the medulla neuropil and arborizations of individual neurons are wider and less distinct than in controls. Analysis of semaphorin function indicates that Semaphorin 1a, acting in a subset of medulla neurons, is the primary partner for Plexin A in medulla lamination. Removal of the cytoplasmic domain of endogenous Plexin A has little effect on the formation of medulla layers; however, both null and cytoplasmic domain deletion mutations of Plexin A result in an altered overall shape of the medulla neuropil. These data suggest that Plexin A acts as a receptor to mediate morphogenesis of the medulla neuropil, and as a ligand for Semaphorin 1a to subdivide it into layers. Its two independent functions illustrate how a few guidance molecules can organize complex brain structures by each playing multiple roles.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lobo Óptico de Animais não Mamíferos
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Receptores de Superfície Celular
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Neurópilo
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Proteínas de Drosophila
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Semaforinas
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Morfogênese
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Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article