Azaphilone pigments from the marine-derived Penicillium sclerotium UJNMF 0503 and their neuroprotective potential against H2O2-induced cell apoptosis through modulating PI3K/Akt pathway.
Bioorg Chem
; 148: 107434, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38744168
ABSTRACT
Azaphilones represent a particular group of fascinating pigments from fungal source, with easier industrialization and lower cost than the traditional plant-derived pigments, and they also display a wide range of pharmacological activities. Herein, 28 azaphilone analogs, including 12 new ones, were obtained from the fermentation culture of a marine fungus Penicillium sclerotium UJNMF 0503. Their structures were elucidated by MS, NMR and ECD analyses, together with NMR and ECD calculations and biogenetic considerations. Among them, compounds 1 and 2 feature an unusual natural benzo[d][1,3]dioxepine ring embedded with an orthoformate unit, while 3 and 4 represent the first azaphilone examples incorporating a novel rearranged 5/6 bicyclic core and a tetrahydropyran ring on the side chain, respectively. Our bioassays revealed that half of the isolates exhibited neuroprotective potential against H2O2-induced injury on RSC96 cells, while compound 13 displayed the best rescuing capacity toward the cell viability by blocking cellular apoptosis, which was likely achieved by upregulating the PI3K/Akt signaling pathway.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Penicillium
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Pigmentos Biológicos
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Benzopiranos
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Apoptose
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Fármacos Neuroprotetores
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Fosfatidilinositol 3-Quinases
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Relação Dose-Resposta a Droga
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Proteínas Proto-Oncogênicas c-akt
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Peróxido de Hidrogênio
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article