Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneurons.
Neuron
; 112(12): 2031-2044.e7, 2024 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-38754414
ABSTRACT
The patterns of synaptic connectivity and physiological properties of diverse neuron types are shaped by distinct gene sets. Our study demonstrates that, in the mouse forebrain, the transcriptional profiles of inhibitory GABAergic interneurons are regulated by Nr4a1, an orphan nuclear receptor whose expression is transiently induced by sensory experiences and is required for normal learning. Nr4a1 exerts contrasting effects on the local axonal wiring of parvalbumin- and somatostatin-positive interneurons, which innervate different subcellular domains of their postsynaptic partners. The loss of Nr4a1 activity in these interneurons results in bidirectional, cell-type-specific transcriptional switches across multiple gene families, including those involved in surface adhesion and repulsion. Our findings reveal that combinatorial synaptic organizing codes are surprisingly flexible and highlight a mechanism by which inducible transcription factors can influence neural circuit structure and function.
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Base de dados:
MEDLINE
Assunto principal:
Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares
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Neurônios GABAérgicos
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Interneurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article