An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging.
Molecules
; 29(10)2024 May 19.
Article
em En
| MEDLINE
| ID: mdl-38792250
ABSTRACT
Monitoring hydrogen sulfide (H2S) in living organisms is very important because H2S acts as a regulator in many physiological and pathological processes. Upregulation of endogenous H2S concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe HND with aggregation-induced emission was designed. Impressively, HND exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 µM) for H2S in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism between HND and H2S was conducted by Job's plot, HR-MS, and DFT. In particular, HND was successfully employed to detect H2S in HeLa cells.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Corantes Fluorescentes
/
Sulfeto de Hidrogênio
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article