Integrin-Targeting Strategies for Adenovirus Gene Therapy.
Viruses
; 16(5)2024 05 13.
Article
em En
| MEDLINE
| ID: mdl-38793651
ABSTRACT
Numerous human adenovirus (AdV) types are endowed with arginine-glycine-aspartic acid (RGD) sequences that enable them to recognize vitronectin-binding (αv) integrins. These RGD-binding cell receptors mediate AdV entry into host cells, a crucial early step in virus infection. Integrin interactions with adenoviruses not only initiate receptor-mediated endocytosis but also facilitate AdV capsid disassembly, a prerequisite for membrane penetration by AdV protein VI. This review discusses fundamental aspects of AdV-host interactions mediated by integrins. Recent efforts to re-engineer AdV vectors and non-viral nanoparticles to target αv integrins for bioimaging and the eradication of cancer cells will also be discussed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
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Integrinas
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Internalização do Vírus
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article