Evaluation of Phytochemistry and Antidiabetic Potential of an Astragalus Species (Astragalus kurdicus Boiss.).
Chem Biodivers
; 21(8): e202400699, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38860322
ABSTRACT
Astragalus kurdicus Boiss. roots are used in folk medicine for antidiabetic purposes. Different Astragalus plant metabolites have a notable potential for antidiabetic activity through varying mechanisms. Herein, this study is designed to assess the antidiabetic activity of Astragalus kurdicus total (AKM methanol extract, yield 14.53 %) and sub-extracts (AKB n-butanol, AKC chloroform, AKW water, AKH hexane extracts), utilizing a range of diabetes-related inâ
vitro methodologies, and to investigate the chemical composition of the plant. The highest astragaloside and saponin content was seen in AKB extract. Among the measured saponins, the abundance of Astragalosideâ
IV (27.41â
µg/mg in AKM) was the highest in high-performance thin-layer chromatography (HPTLC) analysis. Furthermore, flavonoid-rich AKC was found to be mostly responsible for the high antioxidant activity. According to the results of the activity tests, AKW was the most active extract in protein tyrosine phosphatase 1â
B (PTP1B), dipeptidyl peptidaseâ
IV (DPP4), and α-amylase inhibition tests (percent inhibitions are 87.17 %, 82.4 %, and 91.49 % respectively, at 1â
mg/mL). AKM and AKW demonstrated the highest efficacy in stimulating the growth of prebiotic microorganisms and preventing the formation of advanced glycation end products (AGEs). Thus, for the first time, the antidiabetic activity of A. kurdicus was evaluated from various perspectives.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Astrágalo
/
Hipoglicemiantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article