Responsive Versus Continuous Deep Brain Stimulation for Speech in Essential Tremor: A Pilot Study.

Cernera, Stephanie; Long, Sarah; Kelberman, Madison; Hegland, Karen W; Hicks, Julie; Smith-Hublou, May; Taylor, Bryn; Mou, Yuhan; de Hemptinne, Coralie; Johnson, Kara A; Cagle, Jackson N; Moore, Kathryn; Foote, Kelly D; Okun, Michael S; Gunduz, Aysegul

Cernera, Stephanie; Long, Sarah; Kelberman, Madison; Hegland, Karen W; Hicks, Julie; Smith-Hublou, May; Taylor, Bryn; Mou, Yuhan; de Hemptinne, Coralie; Johnson, Kara A; Cagle, Jackson N; Moore, Kathryn; Foote, Kelly D; Okun, Michael S; Gunduz, Aysegul.

Afiliação

Cernera S; J. Crayton Pruitt Department of Biomedical Engineering, Gainesville, Florida, USA.
Long S; J. Crayton Pruitt Department of Biomedical Engineering, Gainesville, Florida, USA.
Kelberman M; J. Crayton Pruitt Department of Biomedical Engineering, Gainesville, Florida, USA.
Hegland KW; Department of Speech, Language, and Hearing Sciences, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Hicks J; Department of Neurologic Rehabilitation, Stanford Neuroscience Health Center, Palo Alto, California, USA.
Smith-Hublou M; Department of Speech, Language, and Hearing Sciences, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Taylor B; Department of Speech, Language, and Hearing Sciences, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Mou Y; Department of Speech, Language, and Hearing Sciences, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
de Hemptinne C; Department of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Johnson KA; Department of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Cagle JN; Department of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Moore K; Department of Neurology, Duke University, Durham, North Carolina, USA.
Foote KD; Department of Neurosurgery, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Okun MS; Department of Neurology, Norman Fixel Institute for Neurological Diseases, Gainesville, Florida, USA.
Gunduz A; J. Crayton Pruitt Department of Biomedical Engineering, Gainesville, Florida, USA.

Mov Disord ; 2024 Jun 15.

Article em En | MEDLINE | ID: mdl-38877761

ABSTRACT

ABSTRACT

BACKGROUND:

Responsive deep brain stimulation (rDBS) uses physiological signals to deliver stimulation when needed. rDBS is hypothesized to reduce stimulation-induced speech effects associated with continuous DBS (cDBS) in patients with essential tremor (ET).

OBJECTIVE:

To determine if rDBS reduces cDBS speech-related side effects while maintaining tremor suppression.

METHODS:

Eight ET participants with thalamic DBS underwent unilateral rDBS. Both speech evaluations and tremor severity were assessed across three conditions (DBS OFF, cDBS ON, and rDBS ON). Speech was analyzed using intelligibility ratings. Tremor severity was scored using the Fahn-Tolosa-Marin Tremor Rating Scale (TRS).

RESULTS:

During unilateral cDBS, participants experienced reduced speech intelligibility (P = 0.025) compared to DBS OFF. rDBS was not associated with a deterioration of intelligibility. Both rDBS (P = 0.026) and cDBS (P = 0.038) improved the contralateral TRS score compared to DBS OFF.