Application of mendelian randomization in ocular diseases: a review.
Hum Genomics
; 18(1): 66, 2024 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-38886833
ABSTRACT
Ocular disorders can significantly lower patients' quality of life and impose an economic burden on families and society. However, for the majority of these diseases, their prevalence and mechanisms are yet unknown, making prevention, management, and therapy challenging. Although connections between exposure factors and diseases can be drawn through observational research, it is challenging to rule out the interference of confounding variables and reverse causation. Mendelian Randomization (MR), a method of research that combines genetics and epidemiology, has its advantage to solve this problem and thus has been extensively utilized in the etiological study of ophthalmic diseases. This paper reviews the implementation of MR in the research of ocular diseases and provides approaches for the investigation of related mechanisms as well as the intervention strategies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oftalmopatias
/
Análise da Randomização Mendeliana
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article