Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
Chem Commun (Camb)
; 60(55): 7025-7028, 2024 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-38888299
ABSTRACT
We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, which relies on the conjugate addition-elimination mechanism of Michael acceptors for the traceless release of therapeutics. In a proof-of-principle study, we translate our findings to exhibit potent thiol-cleavable antibiotic prodrugs and antibody-drug conjugates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
Pró-Fármacos
/
Imunoconjugados
/
Liberação Controlada de Fármacos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article