Advances in Integrated Multi-omics Analysis for Drug-Target Identification.
Biomolecules
; 14(6)2024 Jun 14.
Article
em En
| MEDLINE
| ID: mdl-38927095
ABSTRACT
As an essential component of modern drug discovery, the role of drug-target identification is growing increasingly prominent. Additionally, single-omics technologies have been widely utilized in the process of discovering drug targets. However, it is difficult for any single-omics level to clearly expound the causal connection between drugs and how they give rise to the emergence of complex phenotypes. With the progress of large-scale sequencing and the development of high-throughput technologies, the tendency in drug-target identification has shifted towards integrated multi-omics techniques, gradually replacing traditional single-omics techniques. Herein, this review centers on the recent advancements in the domain of integrated multi-omics techniques for target identification, highlights the common multi-omics analysis strategies, briefly summarizes the selection of multi-omics analysis tools, and explores the challenges of existing multi-omics analyses, as well as the applications of multi-omics technology in drug-target identification.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genômica
/
Proteômica
/
Descoberta de Drogas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article