Your browser doesn't support javascript.
loading
DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.
Torres, Viviana; Pérez-Montesino, Jesica; Fernández-Santiago, Rubén; Fernández, Manel; Camara, Ana; Compta, Yaroslau; Martí, María-José; Guerra Beltran, Àlex; Rios, José; Valldeoriola, Francesc; Ezquerra, Mario.
Afiliação
  • Torres V; Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut de Neurociencies UBNeuro, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
  • Pérez-Montesino J; Lab of Parkinson's disease and other Neurodegenerative Movement Disorders: Clinical and Experimental Research, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Catalonia, Spain.
  • Fernández-Santiago R; Lab of Parkinson's disease and other Neurodegenerative Movement Disorders: Clinical and Experimental Research, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Catalonia, Spain.
  • Fernández M; Lab of Parkinson's disease and other Neurodegenerative Movement Disorders: Clinical and Experimental Research, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Catalonia, Spain.
  • Camara A; Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut de Neurociencies UBNeuro, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
  • Compta Y; Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut de Neurociencies UBNeuro, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
  • Martí MJ; Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut de Neurociencies UBNeuro, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
  • Guerra Beltran À; Lab of Parkinson's disease and other Neurodegenerative Movement Disorders: Clinical and Experimental Research, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Catalonia, Spain.
  • Rios J; Department of Clinical Pharmacology, Hospital Clinic, and Medical Statistics Core Facility, Institutd'InvestigacionsBiomèdiques August Pi ISunyer (IDIBAPS), Barcelona, Catalonia, Spain.
  • Valldeoriola F; Biostatistics Unit, School of Medicine, UniversitatAutònoma de Barcelona, Barcelona, Catalonia, Spain.
  • Ezquerra M; Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut de Neurociencies UBNeuro, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
Ann Clin Transl Neurol ; 2024 Jul 01.
Article em En | MEDLINE | ID: mdl-38952083
ABSTRACT
Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article