Thrombectomy Plus Intra-Arterial Thrombolysis Versus Thrombectomy for Acute Large Vessel Occlusions: a Matched-Control Study.
Clin Neuroradiol
; 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38953962
ABSTRACT
AIM:
We conducted a matched-control analysis to compare the outcomes of large vessel occlusion (LVO) patients treated with mechanical thrombectomy (MT) plus Intra-arterial thrombolysis (IAT) versus those treated with MT alone.METHODS:
The subjects of this study were chosen from ANGEL-ACT registry. All patients who received MT were identified and categorized into two groups "MTâ¯+ IAT" and "MT," based on whether or not they received additional intra-arterial medication IAT during the MT procedure. After being subjected to 11 propensity score matching, the outcome measures, including modified Rankin Scale (mRS) score at 90 days, successful recanalization at the final angiogram, symptomatic intracranial hemorrhage (sICH) within 36â¯h, and death within 90 days, were compared.RESULTS:
The study encompassed a total of 1607 patients, with 641 individuals assigned to the MTâ¯+ IAT group and 966 to the MT group. After applying propensity score matching, a total of 524 pairs were identified for comparison. The results indicated that there were no significant differences between the two groups with regard to the modified Rankin Scale (mRS) score (median 3 vs. 3 points; Pâ¯= 0.83), successful recanalization (89.9 vs. 88.9%; Pâ¯= 0.62), sICH (8.3 vs. 8.7%; Pâ¯= 0.79), and death (15.5 vs. 16.4%; Pâ¯= 0.70).CONCLUSIONS:
IAT during MT does not confer an elevated risk of sICH or mortality. Furthermore, the combination of MT and IAT may produce comparable functional outcomes in comparison to MT alone, when treating acute LVO patients.
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MEDLINE
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Ano de publicação:
2024
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Article