Phycobiliprotein from Arthrospira maxima: Conversion to nanoparticles by high-energy ball milling, structural characterization, and evaluation of their anti-inflammatory effect.
Int J Biol Macromol
; 275(Pt 2): 133679, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38971282
ABSTRACT
Arthrospira maxima is a source of phycobiliproteins with different nutraceutical properties, e.g. antioxidant and anti-inflammatory activities. The current study was aimed at the elaboration, characterization, and evaluation of the anti-inflammatory effect of the phycobiliprotein nanoparticles extracted from Arthrospira maxima. Previously freeze-dried phycobiliproteins were milled by high-energy ball milling until reaching a nanometric size (optimal time 4 h). Microscopy techniques were used for the characterization of the size and morphology of phycobiliproteins nanoparticles. Additionally, a spectroscopic study evidenced that nanosized reduction induced an increase in the chemical functional groups associated with its anti-inflammatory activity that was tested in a murine model, showing an immediate inflammatory effect. The novelty and importance of this contribution was to demonstrate that high energy ball milling is an emerging and green technology that can produce phycobiliprotein nanoparticles on a large-scale, without the use of organic solvents, to test their nutraceutical properties in a biological model by intragastric administration.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Spirulina
/
Ficobiliproteínas
/
Nanopartículas
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article