Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis.
J Asian Nat Prod Res
; 26(11): 1320-1327, 2024 Nov.
Article
em En
| MEDLINE
| ID: mdl-38973288
ABSTRACT
Two new cucurbitane-type triterpenoid saponins, 2,20ß,22ß-trihydroxy-16α,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O-ß-D-glucopyranoside (1), 2,20ß,22α-trihydroxy-16α,23(S)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-O-ß-D-glucopyranoside (2) were isolated from the fruit of Citrullus colocynthis (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 µM against paracetamol-induced HepG2 cell damage.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Triterpenos
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Citrullus colocynthis
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Frutas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article