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Discovery of an antimalarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity.
Kimishima, Aoi; Nishitomi, Atsuka; Tsuruoka, Iori; Sakai, Katsuyuki; Hokari, Rei; Honsho, Masako; Honma, Sota; Ono, Yuki; Kondo, Naozumi; Tsutsumi, Hayama; Kikuchi, Yuta; Tokiwa, Toshiyuki; Kojima, Hiroki; Higo, Mayuka; Nonaka, Kenichi; Inahashi, Yuki; Iwatsuki, Masato; Fuji, Shin-Ichi; Jang, Jun-Pil; Jang, Jae-Hyuk; Chinen, Takumi; Usui, Takeo; Asami, Yukihiro.
Afiliação
  • Kimishima A; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Nishitomi A; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Tsuruoka I; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Sakai K; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Hokari R; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Honsho M; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Honma S; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Ono Y; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Kondo N; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Tsutsumi H; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Kikuchi Y; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Tokiwa T; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Kojima H; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Higo M; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Nonaka K; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Inahashi Y; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Iwatsuki M; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Fuji SI; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Jang JP; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Jang JH; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Chinen T; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
  • Usui T; Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
  • Asami Y; Omura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
Biosci Biotechnol Biochem ; 88(10): 1212-1216, 2024 Sep 20.
Article em En | MEDLINE | ID: mdl-38982331
ABSTRACT
In this paper, we describe our discovery of burnettiene A (1) as an antimalarial compound from the culture broth of Lecanicillium primulinum (current name Flavocillium primulinum) FKI-6715 strain utilizing our original multidrug-sensitive yeast system. This polyene-decalin polyketide natural product was originally isolated as an antifungal active compound from Aspergillus burnettii. However, the antifungal activity of 1 has been revealed in only one fungal species, and the mechanism of action of 1 remains unknown. After the validation of mitochondrial function inhibitory of 1, we envisioned a new antimalarial drug discovery platform based on mitochondrial function inhibitory activity. We evaluated antimalarial activity and 1 showed antimalarial activity against Plasmodium falciparum FCR3 (chloroquine sensitive) and the K1 strain (chloroquine resistant). Our study revealed the utility of our original screening system based on a multidrug-sensitive yeast and mitochondrial function inhibitory activity for the discovery of new antimalarial drug candidates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Saccharomyces cerevisiae / Mitocôndrias / Antimaláricos Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Saccharomyces cerevisiae / Mitocôndrias / Antimaláricos Idioma: En Ano de publicação: 2024 Tipo de documento: Article