Comparison of therapeutic agents' short-term effects on facial and scalp actinic keratosis: A network meta-analysis.
J Cosmet Dermatol
; 2024 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-39044451
ABSTRACT
BACKGROUND:
Care for actinic keratosis (AK) can be improved with more knowledge on the relative of effect of indicated therapies.OBJECTIVES:
Using network meta-analyses, we quantitatively determined the comparative "short-term" effects of interventions in adults with facial and scalp AK.METHODS:
On February 28, 2023, evidence from the peer-reviewed literature was systematically obtained from OVID, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov. We analyzed data from studies published in English, of a trial design, and investigating the effect of an actinic keratosis monotherapy. Patient complete clearance, patient partial clearance or lesion-specific clearance across adults were analyzed at 8-12 weeks after therapy. Patient complete clearance pertained to proportion of participants who experienced complete clearance of actinic keratosis lesions; patient partial clearance corresponded to percentage of subjects who achieved at least 75% clearance of actinic keratosis lesions; lesion-specific clearance represented the percentage of all lesions that were cleared. In the main (i.e., base) analyses, nodes were analyzed only at the level of the agent.RESULTS:
Data from a total of 84 studies were used-across which 22 active agents were identified. Estimates of interventions' surface under the cumulative ranking curve rankings and (pairwise) relative effects were estimated. Across the three outcomes, fluorouracil 5% was ranked the most effective.CONCLUSIONS:
Our work is the first to provide information on covariate-adjusted relative effects of actinic keratosis therapies- including the more recently reported treatments-for the face and scalp; this knowledge may help physicians and patients make more informed decisions.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2024
Tipo de documento:
Article