Mouse cytomegalovirus lacking sgg1 shows reduced import into the salivary glands.
J Gen Virol
; 105(8)2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-39093048
ABSTRACT
Cytomegaloviruses (CMVs) transmit via chronic shedding from the salivary glands. How this relates to the broad cell tropism they exhibit in vitro is unclear. Human CMV (HCMV) infection presents only after salivary gland infection is established. Murine CMV (MCMV) is therefore useful to analyse early infection events. It reaches the salivary glands via infected myeloid cells. Three adjacent spliced genes designated as m131/129 (MCK-2), sgg1 and sgg1.1, positional homologues of the HCMV UL128/130/131 tropism determinants, are implicated. We show that a sgg1 null mutant is defective in infected myeloid cell entry into the salivary glands, a phenotype distinct from MCMV lacking MCK-2. These data point to a complex, multi-step process of salivary gland colonization.
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Base de dados:
MEDLINE
Assunto principal:
Glândulas Salivares
/
Muromegalovirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article