Cardiorespiratory Fitness Benefits of High-Intensity Interval Training After Stroke: A Randomized Controlled Trial.
Stroke
; 55(9): 2202-2211, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39113181
ABSTRACT
BACKGROUND:
Limited evidence supports the effects of short-interval high-intensity interval training (HIIT) for improving cardiorespiratory fitness (VÌO2peak) after stroke. We aimed to compare the effects of 12 weeks of short-interval HIIT versus moderate-intensity continuous training (MICT) on VÌO2peak, cardiovascular risk factors, and mobility outcomes among individuals ≥6 months poststroke.METHODS:
This study was a multi-site, 12-week randomized controlled trial (NCT03614585) with an 8-week follow-up. Participants were randomized into 3 d/wk of HIIT (10×1 minute 80%-100% heart rate reserve interspersed with 1 minute 30% heart rate reserve [19 minutes]) or MICT (20-30 minutes 40%-60% heart rate reserve). Secondary outcomes of the trial, including VÌO2peak, cardiovascular risk factors (carotid-femoral pulse wave velocity, blood pressure, and waist-hip ratio), and mobility (6-minute walk test, 10 m gait speed), were reported. Linear mixed model analyses with a group×study time point interaction evaluated between-group differences.RESULTS:
Of the 305 potential participants, 82 consented (mean [SD] age 64.9 [9.3] years, 32 females [39%], 1.8 [1.2] years poststroke) and were randomized to HIIT (n=42, mean [SD] baseline VÌO2peak 17.3 [5.9] mL/kg·min) or MICT (n=40, mean [SD] baseline VÌO2peak 17.2 [6.0] mL/kg·min). Participants attended 82% of visits (n=2417/2952). No adverse events occurred during the study period. A significant group×study time point interaction was found (χ2=8.46; P=0.015) for VÌO2peak at 12 weeks (mean difference, 1.81 [95% CI, 0.58-3.04]; P=0.004) whereby the HIIT group had greater gains in VÌO2peak (∆3.52 mL/kg·min [95% CI, 2.47-4.57]; P<0.001) compared with the MICT group (∆1.71 mL/kg·min [95% CI, 0.55-2.86]; P=0.001). There was no between-group difference in VÌO2peak (mean difference, 1.08 [95% CI, -0.26 to 2.42]; P=0.11) at 8-week follow-up. No group×study time point interactions were found for cardiovascular risk factors or mobility outcomes.CONCLUSIONS:
Short-interval HIIT may be an effective alternative to MICT for improving VÌO2peak at 12 weeks postintervention. REGISTRATION URL https//clinicaltrials.gov; Unique identifier NCT03614585.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
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Reabilitação do Acidente Vascular Cerebral
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Treinamento Intervalado de Alta Intensidade
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Aptidão Cardiorrespiratória
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article