Wogonin Inhibits Apoptosis and Necroptosis Induced by Nephropathogenic Infectious Bronchitis Virus in Chicken Renal Tubular Epithelial Cells.
Int J Mol Sci
; 25(15)2024 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-39125764
ABSTRACT
NIBV is an acute and highly contagious virus that has a major impact on the poultry industry. Wogonin, as a flavonoid drug, has antiviral effects, but there have been no reports indicating its role in renal injury caused by NIBV infection. The aim of this study is to investigate the antiviral effect of wogonin against NIBV. Renal tubular epithelial cells were isolated and cultured, and divided into four groups Con, Con+Wog, NIBV and NIBV+Wog. We found that wogonin significantly inhibited the copy number of NIBV and significantly alleviated NIBV-induced cell apoptosis and necrosis. Moreover, wogonin inhibited the reduction in mitochondrial membrane potential and the aberrant opening of mPTP caused by NIBV. In conclusion, wogonin can protect renal tubular epithelial cells from damage by inhibiting the replication of NIBV and preventing mitochondrial apoptosis and necroptosis induced by NIBV.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Galinhas
/
Apoptose
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Flavanonas
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Células Epiteliais
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Necroptose
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Túbulos Renais
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article