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A phase 2 trial of mini-hyper-CVD, blinatumomab, and ponatinib in Philadelphia positive acute lymphoblastic leukemia.
Jen, Wei-Ying; Jabbour, Elias; Short, Nicholas J; Issa, Ghayas C; Haddad, Fadi G; Jain, Nitin; Pemmaraju, Naveen; Daver, Naval G; Masarova, Lucia; Borthakur, Gautam; Chien, Kelly; Garris, Rebecca; Kantarjian, Hagop M.
Afiliação
  • Jen WY; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Jabbour E; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Short NJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Issa GC; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Haddad FG; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Jain N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Pemmaraju N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Daver NG; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Masarova L; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Chien K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Garris R; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Kantarjian HM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Am J Hematol ; 99(11): 2229-2232, 2024 Nov.
Article em En | MEDLINE | ID: mdl-39194286
ABSTRACT
Twenty adults with newly diagnosed (ND) or relapsed/refractory (RR) Ph-positive acute lymphoblastic leukemia (ALL), or chronic myeloid leukemia in lymphoid blast phase (CML-LBP), were treated with mini-hyperCVD, ponatinib, and blinatumomab. Complete molecular response was achieved in 78% of ND patients, while CR/CRi was achieved in 100% of RR and CML-LBP. The 3-year overall survival rate was 76% (95% CI, 47%-90%).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Protocolos de Quimioterapia Combinada Antineoplásica / Anticorpos Biespecíficos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Imidazóis Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Protocolos de Quimioterapia Combinada Antineoplásica / Anticorpos Biespecíficos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Imidazóis Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article